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30 : Novel research projects

30 : Novel research projects

This work is in fact part of a wider Inserm research programme, centred on pathological brain activities in new-born babies. Particularly with premature births, neonatal suffering can induce cerebral dysfunctions such as epilepsy, mental retard or difficulties to acquire signals and learning. So, at what moment in time do we decide to operate a new-born suffering from epilepsy strokes that resist medicinal treatments?
By way of an introduction Professor Abdellatif El Badia, research scientist at the UTC-LMAC (Applied Mathematics Laboratory, Compiegne), says “The MIFAC project is unique from two points of view: on one hand it attempts to answer of timing via mathematics and digital modelling and on the other by creating a multi-modal tool combining EEC measurements (electro-encephalogram) and near infrared spectrometry”.

An as yet unexplored problem

The MIFAC project has been awarded a 154 00 euro 3 years budget allowance over and combines the talents the Inserm team at the teaching hospital (CHU) at Amiens, the UTC-LMAC laboratory, the basic and applied maths lab called LAMFA (Laboratoire Amiénois de Mathématiques Fondamentales et Appliquées) at the University of Picardie Jules Verne (UPJKV) and the Maths Lab at the University Reims Champagne-Ardenne.
If you wish to design a decision aid tool to be used in the surgery of new-borns, you need to associate the modelling skills and scientific calculations of these 3 laboratories” underlines Abdellatif El Badia. You must also take into account the electric and hemodynamic characteristics of new-born babies. “How can we use resolution protocols that account of the inhomogeneous ‘specifications of new born skulls? The Inserm team has shown that the soft spot fontanel has an impact on localization of pathological areas in the brain, and this is the scientific hurdle we have to overcome in the project” concludes Prof. El Badia.
The soft-spot fontanel modifies the electric and hemodynamic properties of the skull and brain of new-borns – and represents a difficulty that has not been solved to date. Progress in the MIFAC project will be presented in November during the Picardie Region’s special week on research and innovation.

Understanding a new-born human brain